Human Metabolism of a Novel Ketone Ester Does Not Saturate or Display Adaptation at Up to 50 g After One Week of Daily Consumption

Research Reports & Publications


Exogenous ketones represent a convenient way to achieve ketosis in the absence of a ketogenic diet. Ketosis has been associated with increased healthspan in animal models; however, responses to exogenous ketones can be species-specific. In this study, we report on the product kinetics of a novel ketone ester over one week of daily ingestion in healthy adults. Our results show that the ketone diester is hydrolyzed into products that appear in the plasma and undergo conversion to beta-hydroxybutyrate in a serving size-dependent manner.

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